Several pathogens are able to evade immune surveillance by interfering with lymphokine signaling through various molecular mechanisms (reviewed in [58]) The circumsporozoite protein (CSP), one of the most abundant proteins expressed by malaria sporozoites, has been shown to prevent TNFα-induced translocation of NF-κB into the nucleus of HepG2 or HeLa cells thereby inhibiting transcription of NF-κB responsive genes [59]. The gene discussed is NFKB1; the disease is malaria.