CD8A and infection: The notion that a 10 to 20% decrease of MHC class I expression observed in P. berghei infected HC-04 cells at 48 hours post-infection may have no important functional consequences was further supported by our demonstration that such cells exhibited virtually unaltered capacity to stimulate activation of peptide-specific or allogeneic HLA-A2-specific CD8+ T-lymphocytes (Figure 8).