Because autocrine IL-6 in PC14PE6/AS2 cells induces Stat3 activity through a JAK2-dependent signaling pathway to regulate tumor metastasis and the formation of malignant pleural effusion (MPE) [21], the purpose of this study was to clarify whether IL-6/JAK2/Stat3 signaling can induce TF expression in lung adenocarcinoma cells and whether TF expression affects the above-mentioned biological functions. This evidence concerns the gene STAT3 and lung adenocarcinoma.