KEGG categories for down-regulated genes in TIAR-depleted MEF cells were related to pathways in cancer, cytokine-cytokine receptor interaction, MAPK signalling pathway, purine metabolism, regulation of actin cytoskeleton, antigen processing and presentation, hepatitis C, lysosome biology, pyrimidine metabolism and ErbB signalling pathway (Fig. 3D and Fig. S5). The gene discussed is TIAL1; the disease is hepatitis C virus infection.