SLC9A1 and neoplasm: NHE1 is targeted by hypoxia [77] and hypoxia was found to stimulate invadopodial localized NHE1 [11] and, therefore, in this way NHE1 constitutes an important point of integration between the interaction of the tumor cell with the ECM through integrin receptors and the metabolic tumor microenvironment and could also be important for the design of novel anti-metastasis therapies.