EZR and breast neoplasm: We then correlated p-ezrin protein expression measured as above in primary breast tumors with respect to patient clinico-pathological disease characteristics such as age, tumor size, proliferation index (Ki67), presence of regional nodal metastases (Lymph Node), and Progesterone receptor status, tumor cytohistological de-differentiation (Grade), HER2 receptor status and Nottingham Prognostic Index (NPI) (Table 1).