Furthermore, the stimulation of cancer cells to develop invadopodia by plating on ECM, occurs through the formation of a a lipid raft compartmentalized functional protein-lipid-protein “signalsome” formed by NHE1, p-ezrin, PIP2, ß1-integrin and p-NHERF1 that promotes this activation of NHE1. This evidence concerns the gene NHERF1 and cancer.