The ratio of DSC2 to ACTN2 was 38.7 ± 13.8 in ARVD/C, 68.1 ± 12.9 in controls samples (p<0.001, Mann Whitney Test) and 122.8 in the normal heart sample (Figure 2b). This evidence concerns the gene ACTN2 and Arrhythmogenic right ventricular dysplasia.