We observed a significant increase in tumor incidence and severity of neoplastic disease in the K14E6E7/FancD2-/- mice compared to the K14E6E7/FancD2+/+ mice; however, fancD2-deficiency did not increase either readout for tumorigenesis in the K14E6 mice expressing E6 alone. The gene discussed is FANCD2; the disease is neoplasm.