The low female/male ratio of the anti-AQP1-seropositive patients (1.9:1) is identical to that determined for anti-AQP4 antibody-negative NMO patients in a recent large multicenter study [30], but much lower than that of 10.4:1 for the anti-AQP4-positive patients, determined in the same study or the 4.2:1 ratio we found in our anti-AQP4-seropositive patients. The gene discussed is AQP1; the disease is neuromyelitis optica.