The low female-to-male ratio, the absence of coexisting autoimmune diseases (e.g. MG), and the predominance of LETM (with a low incidence of optic neuritis) in the anti-AQP1-seropositive NMOsd patients are similar to the characteristics of anti-AQP4-seronegative NMOsd [30], [33]. This evidence concerns the gene AQP1 and optic neuritis.