In the current work, the asymmetric migration of keratinocytes was evidently inhibited by EGF but not TGF-α and TGF-β1, suggesting that the paracrine pathway of EGF secreted by HF cells has significant impacts on the directed keratinocyte migration and configuration in tissue development and injury repair [45], [46]. This evidence concerns the gene TGFB1 and hydrops fetalis.