As previously reported [19], genes highly expressed in cancer stroma compared to normal stroma, such as BGN, COL1A1, COL1A2, COL5A1, FN1, NID2, COL10A, COL11A1, COL3A1, MMP2, POSTN, SPARC, DST and THBS2, produced high number of RPKM and positively correlated with the gene expression array data (Figure 6 C). The gene discussed is COL5A1; the disease is cancer.