PIK3CA and autism: Six of these functional categories, named Wnt signaling, Glutamatergic/NMDA receptor I and II, IGF-1/PI3K/mTOR, Synaptic and In vitro response (black or red lettering), arise from more than one gene set each, while three categories (Hypoxia response, Axonal and Autism associated)(gray lettering, discussed in File S7, with corresponding Figure S14, Figure S18 and Figure S19 in File S9, respectively), are based on the presence of a single gene set.