Likewise, the most commonly mutated CGNN (Table S9, Panel B) and DGAN (Table S9, Panel C) motifs affected known driver mutations, alongside several novel candidate genes and driver mutations (Table S9), including p53R248G, which has been reported to alter protein function (http://www-p53.iarc.fr), and GRHL3, WNK3, EPHB1, ADCY2, GSK3B and LRRN3, which are not currently listed in the cancer gene census (http://www.sanger.ac.uk/genetics/CGP/Census). The gene discussed is ADCY2; the disease is cancer.