GpA, which we confirmed to be a key mutation hotspot [6], [8], [9], [21], [61], [63] and found to be enriched in sporadically clustered non-synonymous substitutions (Table S10), would therefore yield mutations through electron transfer [36], [37], [42], [69], tissue-specific deamination [33] and photoexcitation, leading to cyclobutane pyrimidine dimers (CPDs) in melanoma [10], [11]. Here, GYPA is linked to melanoma.