IL4 and infection: Immunization significantly increased the levels of signature Th1 (IFN-γ), Th17 (IL-17a) and Th2 (IL-4) cytokine mRNAs in lung tissue of RV1B challenged mice (p<0.01 RV-immunised vs RV-adjuvant at 24 hrs post-infection) (Fig. 3a).