PRNP and Creutzfeldt Jacob disease: To corroborate these novel findings, we also inoculated a second transgenic line expressing HuPrP 117V PrPC, called Tg(HuPrP117V,129V+/+Prnpo/o)-30 (designated 117VV Tg30), with the same three IPD A117V prion isolates in addition to one case of classical CJD and the same case of vCJD (Table 2).