To corroborate these novel findings, we also inoculated a second transgenic line expressing HuPrP 117V PrPC, called Tg(HuPrP117V,129V+/+Prnpo/o)-30 (designated 117VV Tg30), with the same three IPD A117V prion isolates in addition to one case of classical CJD and the same case of vCJD (Table 2). The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.