TP53 and infection: Many of the top upregulated and induced genes and gene networks were associated with immune responses to infection, including interferon and interferon-inducible genes such as phyin1, a potential activator of p53 [43], the inflammasone regulator Gpb5[44] and Rsad2 (a.k.a. viperin), also known to be induced by HCMV [45].