Additional functional studies of Hif1af/f SurfactantCre+ demonstrated a more profound degree of lung inflammation during ALI, including increased pulmonary neutrophil accumulation (Figure 8B), pulmonary IL-6 (Figure 8C), CXCL1 (Figure 8D), and pulmonary TNF-α levels (Figure 8E). Here, CXCL1 is linked to acute respiratory distress syndrome.