In contrast to studies with the HIF1A activator DMOG, we observed increased pulmonary edema (Figure 6A), in conjunction with increased pulmonary and BAL myeloperoxidase levels (Figure 6B,C), attenuated gas exchange (Figure 6D), and decreased survival time during ventilator-induced ALI in mice that were pre-treated with the HIF inhibitor echinomycin (Figure 6E). The gene discussed is HIF1A; the disease is acute respiratory distress syndrome.