MMP-2 and-9 expression of chondrosarcoma and fibrosarcoma cells treated with TNF-α 10 ng/ml were downregulated by NM treatment in a dose-dependent manner with MMP-2 block at 1000 μg/ml NM and MMP-9 total block at 500 μg/ml NM in fibrosarcoma and 99% block at 1000 μg/ml in chondrosarcoma. The gene discussed is MMP9; the disease is fibrosarcoma.