MMP2 and chondrosarcoma: MMP-9 expression was downregulated by doxycycline 100 μM in chondrosarcoma and liposarcoma by 96 and 86%, respectively, while fibrosarcoma MMP-9 expression was completely blocked at 25 μM. Sensitivity of cell lines to EGCG varied in MMP-2 expression, with total block at 25 μM in synovial sarcoma, 50 μM in fibrosarcoma and liposarcoma and 96% block in chondrosarcoma at 100 μM. PMA-induced MMP-9 expression was blocked by EGCG at 25 μM in synovial sarcoma and 100 μM in fibrosarcoma and virtually blocked at 100 μM in chondrosarcoma and liposarcoma.