MTOR and Insulin resistance: A key role in the development of insulin resistance is played by altered lipid metabolism that generates lipid intermediates, which in turn are able to activate different kinases, such as the mammalian target of rapamycin (mTOR), the inhibitor of κB-kinase (IKK), the c-Jun N-terminal kinase (JNK) and the novel protein kinase C (nPKC) [12].