In murine diet-induced NASH model, the early phase of NASH development is characterised by increase of TNF-α-producing KC, which in turn induce, via the production of interferon γ-induced protein-10 (IP-10) and monocyte chemotactic protein-1 (MCP-1), a later infiltration of pro-inflammatory CD11bint Ly6Chi monocytes. Here, TNF is linked to metabolic dysfunction-associated steatohepatitis.