The in vitro study showed that the accumulation of lipids in hepatocytes was associated with increased formation of CML and increased expression of RAGE, plasminogen activator inhibitor-1 (PAI-1), interleukin 8 (IL-8), interleukin 6 (IL-6) and C-reactive protein (CRP). The gene discussed is AGER; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.