KRAS and familial pancreatic carcinoma: In other studies, transfection of the synthetic miRNA (Gli-1-miRNA-3548) and its corresponding duplex (Duplex-3548) significantly inhibits Gli-1, leading to the inhibition of proliferation, delayed cell division, and activation of late apoptosis in MIA-PaCa-2 cancer cells [162]; miR-96 directly targets the KRAS oncogene, and ectopic expression of miR-96 can reduce pancreatic cell proliferation, migration, and invasion, indicating its potential therapeutic role in pancreatic cancer.