Among the 27 pairs of clinical tissues, down-regulation of miR-302b was observed in 22 (81%) HCC samples compared with their adjacent nontumorous liver tissues, whereas up-regulation of EGFR at mRNA level was found in 21 (78%) HCC tissues compared with adjacent nontumorous counterparts (Figure 1A and B). This evidence concerns the gene EGFR and hepatocellular carcinoma.