In addition, potential biomarkers for detection of early HCC[13], such as glypican 3 (GPC3)[14], ADAM metallopeptidase domain 12 (ADAM12)[15], serine/threonine kinase 15 (STK15), phospholipase A2 (PLA2)[16], and heat-shock protein 70 (HSP70)[17] have also been suggested by previous studies. This evidence concerns the gene ADAM12 and hepatocellular carcinoma.