JUN and brain ischemia: JNK3 is the key signal in neuronal apoptosis during brain ischemia [5], and the JNK3 gene knockout not only reduce the c-jun phosphorylation but also protect the brain injury caused by cerebral ischemia/hypoxia [6], so that inhibiting JNK3 expression and neuronal apoptosis maybe one of important methods to prevent and treat cerebral ischemic injury [7].