After treatment with astragalus injection, the expressions of JNK3 mRNA and JNK3 protein of parahippocampal area decreased significantly than those in model group, so reduced the JNK3 protein activity and inhibited neuronal apoptosis, and as a results, reduced the cerebral infarction volume and improved the neuronal structure and neurobehavioral function of rats. The gene discussed is MAPK10; the disease is cerebral infarction.