When breast cancers were divided into two groups according to hormone receptor status, family history was associated with an increased risk of both hormone receptor negative (OR = 3.05, 95% CI = 1.45 to 6.41, P = 0.003) and positive breast cancer (OR = 2.09, 95% CI = 1.16 to 3.78, P = 0.014). The gene discussed is NR4A1; the disease is breast carcinoma.