From published data, the tube test appears to be a very sensitive test of altered social function in genetic mouse models related to ASD, with significant findings in the Fragile X syndrome model [44], the Rett syndrome model [45], the Arx((GCG)10+7) infantile spasms model [46], the Potocki-Lupski model Dp(11)/17/+ mice [47], and the Dhcr7 heterozygous model of Smith-Lemli-Opitz Syndrome [48]. The gene discussed is ARX; the disease is Rett syndrome.