Earlier work from our laboratory has demonstrated that TGFβ treatment causes the dissociation of survivin/XIAP complex through the TGFβ/PKA signaling pathway in poorly metastatic CRC cells with functional TGFβ tumor suppressor signaling (designated CBSRII cells) as opposed to their highly metastatic counterparts deficient in functional TGFβ tumor suppressor signaling (designated CBS cells) [9]. This evidence concerns the gene CBS and neoplasm.