Based on our previous report that TGFβ/PKA signaling mediated induction of cell death in CRC cells and the current finding that OSI-906 mediated PKA activation that was dependent on TGFβ signaling, we hypothesized that OSI-906 treatment would lead to TGFβ/PKA mediated cell death. This evidence concerns the gene TGFB1 and colorectal carcinoma.