Multivariate analysis by Cox's proportional hazard regression model in oligodendroglial tumors identified total 1p/19 codeletion as the main independent prognostic factor (P < 0.0001), followed by the histologic tumor grade (P = 0.001) and the EMP3 promoter hypermethylation (P = 0.071). This evidence concerns the gene EMP3 and oligodendroglial tumor.