Among the histological types, the frequency of EMP3 hypermethylation was higher in tumors with an oligodendroglial component, as oligoastrocytomas (14 of 20 cases, 70%) and oligodendrogliomas (46 of 73, 63%), than in astrocytic tumors (18 of 100 cases, 18%), with statistical significance (P < 0.0001) (Table 2). This evidence concerns the gene EMP3 and oligodendroglioma.