In the whole series of 185 glial tumors, the EMP3 hypermethylation was associated with loss of the 19q13.3 locus, as defined by loss of the two consecutive MLPA probes ZNF342 and PPP1R15A, tightly flanking the EMP3 gene (P = 0.0001). Here, PPP1R15A is linked to glioma.