The one hundred and forty-nine CD patients and 78 controls were classified in 3 different Subgroups according to algorithm-1 based on the presence of symptoms and signs suggestive of CD, anti-TG2 levels, positivity for EMA and for HLA-DQ2 (in cis or in trans), or -DQ8 (Figure 1). The gene discussed is TGM2; the disease is Cowden disease.