TGFB1 and Alzheimer disease: Conflicting results have been reported on SNPs at codon +10 (T/C) with a study showing that the T allele of codon 10 is associated with reduced levels of protein in serum and reduced secretion in HeLa cells [29], while a recent study has demonstrated that the +10 CC genotype is associated with reduced serum levels of TGF-β1 in patients with Mild Cognitive Impairment (MCI) converted into AD [88].