CRKL and chronic myelogenous leukemia, BCR-ABL1 positive: In chronic myeloid leukemia (CML) patients, miR-221was significantly up-regulated during the blast crisis phase and was predicted to target v-crk sarcoma virus CT10 oncogene homolog (avian)-like (CRKL) in the MAPK signaling and phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) in epidermal growth factor receptor (EGFR) signaling associated with CML [94].