Although body weight did not differ, elevated liver 2-AG and AEA, larger adipocytes, higher macrophage accumulation in WAT and elevated plasma leptin levels in mice fed 8 en% may suggest a more obesity prone phenotype and a higher risk of developing obesity and metabolic complications associated with obesity compared to mice fed same amount of fat but with only 1 en% LNA. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.