Thus, we may assume an hypothesis: 3BP could kills the tumours cells by the following determinant factors: (1) increased amounts of MCT 1 may enhance the transport of the compound and produce lethal intracellular levels (Figure 2); (2) increased binding of mitochondrial HK binding to VDAC/ANT/FoF1ATP synthase would affect mitochondrial respiration and thus favour inhibition by 3BP; (3) by lowering the levels of GSH 3BP would not counteract the effects of ROS. Here, HK1 is linked to neoplasm.