Furthermore, several cases of demyelinating events of the nervous system have been reported for anti-tumor necrosis factor (TNF) agents, such as infliximab (Remicade®; Centocor Ortho Biotech), in CD, severe forms of plaque psoriasis, rheumatoid arthritis (RA) and spondyloarthritis[9-11]. Here, TNF is linked to spondyloarthropathy.