Recently, we have found for the first time that RUNX3 knockdown significantly attenuates ADR-mediated apoptotic cell death in p53-proficient U2OS and human lung carcinoma A549 cells but not in p53-deficient human lung carcinoma H1299 and human osteosarcoma SAOS-2 cells [118]. This evidence concerns the gene TP53 and osteosarcoma.