According to our recent results [108], RUNX1 together with p53 accumulated in human osteosarcoma-derived U2OS cell nucleus following ADR exposure, formed a stable complex, and was recruited onto p53-activated promoters including p21WAF1 and BAX, suggesting that RUNX1 might affect the transcriptional activity of p53. The gene discussed is RUNX1; the disease is osteosarcoma.