Although mutant p53 has been considered to be transcriptionally inactive due to the fact that most p53 mutants fail to transactivate p53-inducible genes, it has been shown that mutant p53 has an ability to regulate the expression of the specific set of genes implicated in tumor initiation and maintenance such as MDR-1, c-Myc, c-fos, and HSP70 [82–85]. Here, TP53 is linked to neoplasm.