EGFR and cancer: The Ras/Raf/MAPK cascade can be activated by the epidermal growth factor receptor (EGFR/ErbB1), a member of the ErbB receptor tyrosine kinase family, which is frequently mutated and overexpressed in different human cancers, including glioma, non-small-cell lung carcinoma, ovarian carcinoma, and prostate carcinoma [47].