Additionally, curcumin has been shown to decrease the levels of O2−, XO, MPO and LPO in myocardium elevated the levels of GPx, SOD, CAT and GST, inhibits the development of atherosclerosis in ApoE/LDLR-DKO mice, attenuates global cardiac I/R injury; decreases myocardial MMP-9, IL-6, MCP-1, TNFα, decreases plasma IL-8, IL-10, and cardiac troponin 1 and decreased apoptosis in cardiomyocytes and myocardial Myeloperoxidase (MPO). Here, APOE is linked to atherosclerosis.