ApoE deficient mice fed a diet rich in blueberries showed a recession in the symptoms of atherosclerosis by reducing the number of atherosclerotic lesions and importantly upregulating the synthesis of 4 key antioxidant enzymes in the liver and serum namely SOD 1 and 2, GSR, Thioredoxin (Tnxrd1) and serum Paraoxonase (PON1). The gene discussed is APOE; the disease is atherosclerosis.