Furthermore, curcumin reduced transcript levels of TNFα receptors, diminished nuclear translocation of NFκB affecting gene regulation, and reduced TNFα-induced expression of adhesion molecules characteristic of atherosclerosis such as ICAM-1, MCP-1 and IL-8 mRNA and protein, as well as monocyte adhesion to HUVECs [145]. The gene discussed is CCL2; the disease is atherosclerosis.