The aim of this study was to analyze the association between CD and the TGFB1 (codon 10 T > C - rs1800470; codon 25 G > C - rs1800471) and IL10 (−1082 A > G - rs1800896; -819 T > C - rs1800871; -592 A > C - rs1800872) gene polymorphisms and to examine the association between these polymorphisms and the clinical features of CD, such as age at diagnosis, location, and behavior of the disease in a mixed-race population. Here, IL10 is linked to Cowden disease.