In contrast to the above findings, Pinto-Plata et al., showed a significantly higher level of CRP in COPD patients (50.03 ± 1.51 mg/l) than in smoking (2.02 ± 1.04 mg/l) and non smoking control groups (2.24 ± 1.04 mg/l) (p < 0.001) [6]. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.