Immunohistochemical staining of the xenograft tumors demonstrated that β-catenin, E-cadherin, and Cyclin D1, the target of Wnt signaling, were strongly up-regulated in tumor segregants (TSs) derived from HONE1 hybrids, as compared with control tumors from the parental HONE1 and MCH4.5-2TS cells. The gene discussed is CDH1; the disease is neoplasm.