In comparison with BALB/c mice challenged with a highly virulent influenza strain (V), BALB/c mice challenged with the Ts showed significantly lower levels of S1PR1 mRNA in heart (P < 0.01), spleen (P < 0.01), kidney (P < 0.01), and liver (P < 0.05) (Figure 2B). The gene discussed is S1PR1; the disease is influenza.