As acute exacerbation of asthma might contribute to airway remodeling by changing the levels of biomarkers for oxidative stress and inflammation, we therefore determined plasma levels of 8-isoprostane (biomarker of oxidative stress), CRP (biomarker of systemic inflammation), and total MMP-9 as well as MMP-9 activity in patients with asthma in acute exacerbation and in remission. The gene discussed is CRP; the disease is asthma.