In obesity, there is oversecretion of deleterious proinflammatory molecules like interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), leptin, resistin, retinol binding protein-4, plasminogen activator inhibitor-1 (PAI-1), hepatic growth factor (HGF), and so forth and hyposecretion of beneficial adipokines such as adiponectin and visfatin [68]. Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.