As expected, IN immunization of WT mice significantly reduced both infection (Figure 8A) and inflammatory disease (Figure 8B), however immunization was ineffective in further reducing either infection (Figure 8A) or disease (Figure 8B) in IL-17-deficient mice, most likely due to decreased IFNγ production and the ability to mount a protective Th1 response. The gene discussed is IL17A; the disease is infection.