The chromosomal region 3p21 is subject to frequent loss (heterozygous and homozygous) in multiple tumor types, the RAS association domain family protein 1 A (RASSF1A) gene located in this region, is a putative tumor suppressor which shares high sequence homology with a known mouse protein (Nore1) [11,12]. This evidence concerns the gene RASSF5 and neoplasm.