A common feature of neurodegenerative diseases [such as PD, prion disease, AD, Huntington’s disease and DLB] is the presence of elevated levels of aggregated amyloidogenic proteins [α-Syn, prion, β-amyloid, huntingtin or α-Syn, respectively] [24]; upon aggregation, α-Syn which is normally present in a disordered soluble form, becomes amyloidogenic. Here, HTT is linked to prion disease.