IFNL3 and cryohydrocytosis: Lange et al. in a complementary study based on a greater series of CHC patients (701 cases), detected an association between CYP27B1-1260 promoter polymorphism (rs10877012) and the rate of response to antiviral therapy (p = 0.06) which reached significance (p = 0.02) when the analysis was limited to patients with the IL28B genotype associated with poor response [16].