ZUP1 and cancer: Cisplatin in particular has been widely used in prostate chemotherapy, along with mitoxanthrone and DTX.32 At molecular level, it triggers apoptosis through oxidative stress, p38 kinase activation and mitochondria impairment in different cancer cell types, including prostate cells.33, 34, 35, 36 In our experimental model, we demonstrate for the first time that a specific prostatic DUB, USP2a, protects from drug-induced oxidative stress.