PLA2G2D and colonic neoplasm: The previously reported mitogenic effects of sPLA2s in colon cancer and other cells were also modest[18,19,22,25,26], suggesting that the positive effects of sPLA2s on cell proliferation could, at least in some of these studies, be in fact a consequence of underlying changes in basic lipid metabolism and a pro-survival action, which is most evident under stressful conditions for the cell.