The involvement of sPLA2s in cancer and other diseases has been investigated in relation to their ability to release arachidonic acid (AA) from cell membranes and stimulate, either directly or in coordination with the cytosolic group IVA PLA2 (cPLA2α), the production of eicosanoids, including the mitogenic prostaglandin E2 (PGE2)[12,14,23]. The gene discussed is PLA2G2D; the disease is cancer.