Using Agilent Sureselect 50Mb exome capture and SOLiD sequencing in a trio (an affected father and daughter and unaffected mother) enabled the identification of the PLCG2 as being the gene mutated in Autoinflammatory PLCG2-associated antibody deficiency and immune dysregulation (APLAID) syndrome, an autosomal dominant disease [35]. The gene discussed is PLCG2; the disease is autosomal dominant disease.