From these reviews and others we have identified five melanoma biomarkers consistently associated with melanoma progression – melanoma cell adhesion molecule (MCAM), galectin-3 (Gal-3), matrix metalloproteinase-2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4), and paired box 3 (PAX3). The gene discussed is MCAM; the disease is melanoma.