The interaction of MCAM with VEGFR-2 on melanoma cells remains to be confirmed, although it is known melanoma express VEGF and VEGFR-2, and overexpression of VEGF-A in a melanoma cell line with VEGFR-2 favored cell growth and survival through MAPK and PI3K signaling pathways (126). The gene discussed is VEGFA; the disease is melanoma.