Many studies show PAX3 expression in melanoma, but also in tumors arising from other neural crest-derived tissues, such as medulloblastoma, benign peripheral glial tumor neurofibroma (precursor of malignant nerve sheath tumor), Erwin’s sarcoma, supratentorial primitive neuroectodermal tumor, and pediatric alveolar rhabdomyosarcoma (ARMS) (42–51). The gene discussed is PAX3; the disease is melanoma.