A number of authors have reported data supporting the conclusion that αvβ3 binds active MMP-2 on the surface of melanoma cells (217, 218), others have found MMP-2 to be localized at the leading edge of migrating melanoma cells before αvβ3 (219), or that pro-MMP-2 did not bind αvβ3 (199). Here, MMP2 is linked to melanoma.