LGALS3 and metastatic melanoma: Gal-3 expression has also been positively correlated with tumor thickness, Clarke and Breslow tumor stage, lymphatic invasion, lymph node positivity, and distant metastases (143), although Brown et al. (144) recently reported that Gal-3 expression showed a bi-modal distribution, with increased levels in thin primary melanoma compared to naevi, and a progressive decrease in expression in thicker and metastatic melanoma.