This work suggested Gal-3 could be of prognostic value, as American Joint Committee on Cancer (AJCC) stage 3 and 4 melanoma patients had higher serum Gal-3 levels than patients with AJCC stage 1 and 2 melanoma, and serum measurements could have a role in follow-up and management of stage 3 and 4 melanoma patients (146). The gene discussed is LGALS3; the disease is melanoma.