In humans, cavin-3 is encoded in the 11p15.5 tumor suppressor locus and loss of cavin-3 expression is common in many epithelial and glial derived cancers (Zochbauer-Muller et al., 2005; Lee et al., 2008; Martinez et al., 2009; Tong et al., 2010; Caren et al., 2011; Lee et al., 2011). This evidence concerns the gene CAVIN3 and neoplasm.