CAVIN3 and cancer: Strong selection pressure for loss of cavin-3 in cancer cells is suggested by the observation that while 41% of primary non-small cell lung carcinomas show methylation of their cavin-3 promoters, 81% of these carcinomas (N = 93) lack detectable cavin-3 expression by immunohistochemistry (Zochbauer-Muller et al., 2005).