A potential clue as to the role of cavin-3 in cancer comes from the observation that 35–55% of glial, lung, gastric, ovarian, breast, and colorectal cancers show hypermethylation in their cavin-3 promoters (Xu et al., 2001; Zochbauer-Muller et al., 2005; Lee et al., 2008; Martinez et al., 2009; Tong et al., 2010; Lee et al., 2011). This evidence concerns the gene CAVIN3 and cancer.