AKT1 and cancer: Loss of cavin-3 is common in cancer cells (Xu et al., 2001; Zochbauer-Muller et al., 2005; Lee et al., 2008; Martinez et al., 2009; Tong et al., 2010; Caren et al., 2011; Lee et al., 2011) and many cancer cells show elevated Akt/mTORC1 signaling, aerobic glycolysis and resistance to apoptosis (Manning and Cantley, 2007; DeBerardinis et al., 2008; Duronio, 2008).